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What is Protandim Nrf2 & How Does it Work?

Protandim Nrf2, the discovery that changed everything. It’s one of the most groundbreaking insights into reducing oxidative stress, the cellular damage caused by free radicals. Oxidative stress is a key contributor to the signs of aging, and Protandim Nrf2 Synergizer is the only supplement shown to reduce oxidative stress by 40% in just 30 days. This finding is backed by over 30 independent studies conducted by institutions such as Harvard, Ohio State, and the American Journal of Physiology, among others.

How does it work? Your body produces its own antioxidants to fight free radicals, but production begins to decline in your early 20s. Protandim Nrf2 Synergizer activates pathways to support your body’s ability to produce antioxidants, reduce cellular stress, and repair your own cells. It’s a powerful, patented, all-natural solution to support your body’s healthy aging process.*


Reduce Oxidative Stress by an Average of 40% in 30 Days*

30+ Peer Reviewed Published Studies

17+ United States + International Patents

Increase Glutathione by 300% in Just 120 Days*


Beyond BREATHING oxygen (yes, we create free radicals simply by existing) most of our oxidative stress comes from the taxing environment we live in. Our body’s natural ability to fight free radicals declines sharply with age.

Sedentary Lifestyle

is a risk factor for cardiovascular disease by damaging vascular function through OS.

EMF Radiation

Cell phones, tablets, laptops, WIFI, blue tower, 4G / 5G / LTE, bluetooth, dirty electricity and more!

Chemical Exposure

Studies now point the fact there are over 80,000 (mostly untested) chemicals in our environment.


Causes a rise in particular hormones/adipokines that create low level cellular inflammation.

Poor Diet

GMO’s, gluten, food dyes, preservatives, artificial sweeteners, seed oils, sugar and more!

Psychological Stress

Triggers a cascade stress hormones and cytokines that break down cells + wreak havoc.

Smoking + Alcohol

In addition to secondhand smoke, vaping, and marijuana use causes cellular damage.

Poor Sleep

Not only causes OS but high levels of inflammation impacts sleep quality.


Viral infections can cause a reduction in glutathione, imparing the ability to lower OS.




“Lifeline Therapeutics, Inc. (OTCBB: LFLT) announced data from a human study just published in the scientific journal, Free Radical Biology & Medicine (Jan. 15, 2006), demonstrated Protandim® was able to reduce oxidative stress in men and women. Oxidative stress results when the balance between oxidants and antioxidant enzymes is upset. Oxidative stress, which many authorities believe is central to the cellular aging process, increases as we age. 

In this study, before starting Protandim NRF2 Syngergizer®, study participants, who ranged in age from 20 to 78, showed a strong age-related increase in TBARS. After 30 days of taking Protandim®, a 40 percent average decrease in TBARS was seen, and the age-related increase was eliminated.” 

Read Press Release Here

1,000,000x Stronger Than Dietary Antioxidants Like Vitamin C!*


Used for 4,000 years in Ayurvedic & Chinese cultures, shown to help fight cellular stress, maintain joint health, and aid digestion.*


Contains high concentration of powerful antioxidants and known to support healthy mental processes and cardiovascular health.*


Known to promote cognitive abilities, concentration, and alertness, and studies suggest it provides strong cellular defense.*


Used for 2,000 years to support liver, kidney, and gallbladder function, and studies suggest it supports healthy detoxification.*


The “king of Ayurvedic herbs,” an adaptogen with multiple benefits, including support for memory enhancement and restful sleep.*

Protandim Nrf2 INFO

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Protandim Nrf2 FAQ 

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Studies on Protandim NRF2 Synergizer® have been published and peer-reviewed from some of the world’s most respected research institutions, including:

University of Colorado
Denver Health Medical Center
Children’s Hospital, Denver
Virginia Commonwealth University
Colorado State University
University of Florida
University of Kentucky

University of Michigan
Louisiana State University
Ohio State University
Harvard University
Vanderbilt University
Northwestern, University
National Institute of Aging

Glamorgan University, Wales
Sahlgrenska Uni. Hospital, Sweden
University of Montreal, Quebec
University Hospital, Brno, Czech Republic
Mexican Institute of Social Security, Mexico
VU Uni. Medical Center, Neuroscience Campus
Amsterdam, The Netherlands

To search the connection of oxidative stress to any health concern, simply go to and type in “Oxidative Stress + Health Issue” (ie: Oxidative Stress Cancer, Oxidative Stress Diabetes) etc. 

Click on the buttons below to go directly to and view studies on Oxidative Stress, Protandim NRF2 and NRF2


Search: Oxidative Stress
Search: Protandim
Search: Nrf2

   Conclusions of Protandim and NRF2 Technology:

University of Texas, 2010
“Nrf2 is a guardian of healthspan and the gatekeeper of species longevity…protecting against many age related diseases including cancer and neurodegeneration.”

Washington State University, 2015
“Nrf2 is likely to be the most important health promoting approach in the foreseeable future. Nrf2 may become the most extraordinary therapeutic and preventative breakthrough in the history of medicine.”

Louisiana State University, 2009
“Induction of antioxidant enzymes by Protandim® may serve as a practical and potent approach to cancer prevention.”

National Institute of Aging, 2017
“Protandim® is the only nutritional supplement tested that has been proven to increase the median survival in mice, thus delaying the aging process. It has the potential to extend lifespan and delay disease and dysfunction.”

Protandim Nrf2 Synergizer Clinical Study #1
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